What Most Don’t
See is Exactly
What We Look For

It all began with a simple question to some of the greatest thinkers in medicine. If you could design the perfect health strategy to protect you and your family, what would it look like? The answer to that question is Radence.

This is personalized precision medicine that adheres to a level of detail that those who dedicate their entire lives to the details can get behind. That’s why the elite MDs and PhDs who built it are behind it. And it’s now available to you.

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Transforming Health
with Predictive Medicine

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Healthcare at the leading edge.

We offer our members access to the science that will shape tomorrow’s medicine, today.
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A trusted guide at your side. Always.

We work directly with your clinical care team to personalize and enhance your care.
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Science in continuous action.

We distill layers of complex health data into meaningful, actionable insights.
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Our network is your network.

We provide seamless access to the best precision medicine, specialists, and early detection research available today.

Transforming Health
with Predictive Medicine

001

Healthcare at the leading edge.

We offer our members access to the science that will shape tomorrow’s medicine, today.
002

A trusted guide at your side. Always.

We work directly with your clinical care team to personalize and enhance your care.
003

Science in continuous action.

We distill layers of complex health data into meaningful, actionable insights.
004

Our network is your network.

We provide seamless access to the best precision medicine, specialists, and early detection research available today.

More Time to Make the Most of

Our aim is to radically change the baseline definition of what it means to be going strong at 70, 80, and beyond. Long life and quality of life are no longer mutually exclusive. You can have both. Whatever your age today, that starts now.

Our Approach: Human-Centered and Data-Driven

Assessment

With best-in-class, multimodal testing, using blood biomarkers, proprietary screening protocols, and 1:1 consultations with the leading experts in health span optimization, we uncover the full picture of your health at the highest level of detail.

Analysis

We capture a clear picture of your current health and recommend a leading-edge, curated plan for you and your doctor, guided by your data.

Activation

Fully collaborating with your clinical care team, we create and deliver your comprehensive test results and risk profile with a health span optimization action plan tailored to your unique needs and goals.

“Diseases do not occur overnight. It’s a long, progressive physiological shift. Radence is focused on understanding and delineating that trajectory. Even when a person still feels ‘fine,’ their biology is still evolving...”

Julie Chen
Dr. Julie Chen
Radence Chief Medical Officer

“Our job is to identify the shift, intercept early, and optimize the individual’s current and future health.”

Julie Chen
Dr. Julie Chen
Radence Chief Medical Officer

Science Never Stops

Doctors working together

Defining the Radence Standard of Care

While the healthcare industry is often crowded with buzzwords, Radence is building something deeper, more rigorous, and far more human. At the heart of Radence’s model is early detection for disease interception and enduring support. The Radence journey is about creating a lifelong process of understanding, protecting, and optimizing the health of our members.

Led by Chief Medical Officer Dr. Julie Chen, Radence is defining a higher standard of care than anything else available today. She is a rising star in the field of health span extension through precision medicine in her approach to caring for members.

Beyond Access to Precision Care

Precision programs often involve many modalities and a great deal of data. At Radence, the bar is much higher. Our interpretation of precision medicine involves a multimodal approach, innovative tools, and high-quality data to provide actionable insight that can impact our members’ day-to-day quality of life.

“The beauty and artisanship of our approach lies in selecting the right tools to get an accurate picture of each individual from their health data and creating a highly personalized action plan tailored to each member,” said Dr. Julie Chen. “Providing precision data gives our members some control over their health span. It’s a partnership. Radence gives members clear data-driven guidance and recommendations for an optimized pathway to optimal outcomes. What matters most is the quality of what Radence members receive. From the clinical on-science precision of early detection testing to the accuracy of who our members truly are — that is what leads to reproducibility in our interpretations. Our care model is designed for scientific integrity at every level.”

Radence’s multimodal, multi-layered approach to early detection triangulates insights across tools, organ systems, and time, she explained. “It’s about doing the right tests, not over testing. Quality vs. Quantity,” Dr. Chen said. “It’s about building a more complete picture of your health and reducing the chance of false positives or false negatives that could lead to either unnecessary panic or missed opportunity.”

“While there is significant value in having data, there is an intentional approach to why we gather that data and what we do with it,” she said. “It’s aligned with desired outcomes and personal goals. This is not about gathering random data. The how and the what are based on the why, based on each person’s intentions, goals, and risk factors. That makes it personalized.”

We Walk with You

At Radence, we walk with you. We use what we learn to create a mutual understanding of your health at a cellular level.

“Health is a moving target,” Dr. Chen said. “Diseases evolve. Physiology changes. We grow with our members, so we can see how their bodies are evolving, whether they’re moving toward disease or away from it.”

This continuous relationship enables Radence to detect small shifts that might otherwise be missed. “Our longitudinal approach isn’t just about diagnostics. It’s about building a true health partnership,” she said. “One that is alert, adaptive, and deeply informed.”

The Human Lens

While Radence focuses on science and personalized precision care, what truly guides this innovative model is something deeply human: care as if you’re family.

“When I meet one-on-one with our members, I always ask myself: ‘If this was my parent, my child, my best friend — how would I approach this?’  That’s the lens we bring to every decision,” said Dr. Chen. “Every clinician at Radence is trained not only in the protocols and tools, but in this philosophy. It’s not enough to be highly skilled. Our providers must be deeply invested. If they’re not doing that, they’re not part of Radence.”

The Discipline of Iteration

Medicine moves fast — and Radence does more than keep pace. We lead.

The Radence model is built to never stand still. Whether it’s adding new genes to a genomic panel after just one insight or reevaluating a testing protocol after a single ambiguous case, our clinical team is in constant conversation about continuous improvement.

“There is no static,” Dr. Chen said. “If I don’t like what I’m seeing in a meeting, we iterate. Immediately.”

This commitment to refinement is part of what makes Radence unique.

“We aren’t simply offering what’s available, we are building what should exist,” she said. “Every encounter, every report, every protocol is held to a higher standard, constantly evaluated and pressure tested, focused on the drive to be the best and deliver the best. Always.”

A Curated Experience Rooted in Science

Consistency is not a luxury. It’s a clinical imperative for Dr. Chen and her team at Radence. From the quality of imaging machines to the communication style of our clinicians, Radence is working to ensure that every touchpoint delivers the same level of excellence.

“Whether you’re speaking to a radiologist, internist, or nurse practitioner, you are engaging with one unified standard of care. That level of consistency is rare. And it’s intentional,” Dr. Chen said.

Innovative Care, Rooted in Love

“Radence is not just a system. It’s a mindset. A culture of care rooted in curiosity, rigor, and love. Our members are not patients, they are part of the Radence family,” Dr. Chen said.

To care for someone as if they are family is a high bar.

“It means we don’t accept good enough. It means we question everything. And it means that we are always watching, learning, evolving — so that we can see the stumble before it happens,” Dr. Chen said. “That’s the Radence Standard of Care.”

 

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Dr. Julie Chen, Radence Chief Medical Officer

Redesigning Medicine from the Inside Out

In today’s rapidly evolving medical landscape, physicians are increasingly called upon to balance innovation with evidence, patient expectations with system constraints, and emerging tools with deeply rooted traditions. For Dr. Julie Chen, a board-certified internal medicine specialist physician with fellowship training in integrative medicine with years of experience as a leader in genomic precision medicine — a specialty that focuses on the future of healthcare, reclaiming what medicine was always meant to be: comprehensive, compassionate, and grounded in science.

“We all went into medicine to help people heal,” said Dr. Chen. “But many of us find ourselves navigating systems that are optimized for disease management, not for prevention. That isn’t a personal failing. It’s a systems problem.”

Dr. Chen currently serves as Chief Medical Officer at Radence, a company pioneering a multimodal precision-based model of care. At its core, Radence seeks to identify and intervene on disease risk earlier than traditional models allow — not in response to pathology, but in anticipation of it.

“Most of what we see in chronic disease is not sudden,” Dr. Chen said. “It’s a long, progressive breakdown of physiologic resilience. Our job is to understand that trajectory and to act on it early, when the patient still feels ‘fine,’ but the biology is already shifting.”

Addressing the Limits of Traditional Care

Dr. Chen has tremendous respect for the goals of current conventional medicine. However, she sees it as incomplete.

“Our traditional system is remarkable at acute intervention,” she said. “But it’s less equipped to manage early disease interception of the slow-developing dysfunctions that characterize so many of our biggest health challenges — cancer, cardiovascular disease, neurodegeneration, metabolic dysfunction.”

She points to constraints many physicians know well: 15-minute visits, fragmented specialty care, limited tools for subclinical disease, and a reactive rather than predictive infrastructure.

“It’s not that doctors don’t care about prevention or early detection,” Dr. Chen said. “It’s that the system doesn’t always give them the time or tools to do it well.”

A Multimodal, Systems-Oriented Approach

What Radence offers is a framework to augment what clinicians are already doing. Its platform brings together genomics, imaging, metabolomics, advanced blood work, and wearable data to generate a comprehensive picture of an individual’s health trajectory.

“We use high-resolution tools to pick up signals that traditional workups might miss. But more importantly, we translate those findings into real-world decisions. We help people understand their risk and take steps to modify it,” Dr. Chen said.

That process is deeply collaborative. Radence doesn’t seek to replace a patient’s care team. It works in partnership with referring clinicians, offering extended assessments and evidence-based recommendations that complement existing care plans.

“This is not about displacing primary care or specialists. It’s about supporting them with another layer of data and insight,” Dr. Chen said. “We know that no one understands the patient better than their own doctor. Our role is to enhance that relationship, not compete with it.”

Precision without Elitism

One concern often raised about precision or concierge medicine is equity—that these models only serve the affluent. Dr. Chen sees this differently.

“Early adopters always pave the way for broader access,” Dr. Chen said. “Every major medical advance — from medications to whole-genome sequencing — started in specialized settings before becoming standard. What we’re building now will eventually become more scalable. But someone has to lead, and that’s where Radence comes in.”

To that end, the company is investing in outcomes research, clinical validation, and real-world evidence to support its protocols. “We’re not just innovating,” she said. “We’re validating. We’re contributing to the science so this model can expand.”

Data Alone is Not Enough

Despite Radence’s technological sophistication, Dr. Chen emphasizes that data is only as powerful as the context it’s given.

“We’re not just handing people dashboards,” she said. “We’re walking them through it. We pair high-resolution diagnostics with meaningful conversation. That’s where trust is built. That’s how change happens.”

The result is more than early detection testing. It’s engagement.

“When patients understand their physiology, when they see the why behind a recommendation, they are more likely to act,” Dr. Chen said. “We’re not just changing lab values. We’re changing behavior.”

Four Disease Domains, One Coordinated Strategy

Radence begins by focusing on the survival layer — the four disease categories responsible for the majority of premature mortality and morbidity: cancer, cardiovascular disease, metabolic dysfunction, and neurodegeneration. These are not isolated silos, Dr. Chen noted. They are deeply interconnected through shared pathways of inflammation, oxidative stress, metabolic regulation, and genetic risk.

“If you have insulin resistance, you’re not just at risk for diabetes. You’re at increased risk for dementia and cardiovascular disease,” she said. “We take a systems-level view of risk. That means we can intervene in ways that impact multiple domains simultaneously.”

From there, the platform expands to assess autoimmune risks, hormone regulation, immune function, and more.

“We meet the patient where they are, and then we grow with them,” Dr. Chen said. “It’s dynamic. It’s continuous. And it’s deeply personal.”

An Invitation to the Medical Community

For Dr. Chen, one of the most innovative aspects of Radence is the partnership.

“We want to work with clinicians who are curious, collaborative, and committed to pushing the standard of care forward,” Dr. Chen said. “Whether you’re a cardiologist, internist, neurologist, or family physician, there’s a place for you in this model. We need your insight. Your experience. Your trust.”

She knows that change is never easy, especially in a field as high-stakes and evidence-driven as medicine. But she also knows that physicians are problem-solvers.

“We’re not asking people to abandon conventional care,” Dr. Chen said. “We’re inviting them to build on it. To extend it. To make it better.”

In an era where both patients and clinicians are demanding more — more answers, more support, more continuity, Dr. Chen sees Radence as a blueprint for what’s possible.

“This is the future of care: science-led, system-aware, patient-centered, and clinician-empowering,” Dr. Chen said. “We’re not starting over. We’re starting ahead.”

 

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Screen showing various biological systems

Embracing Early Detection

For many, healthcare begins when something feels wrong — a nagging pain, unusual fatigue, or symptoms that can no longer be ignored. That moment of concern leads to appointments, tests, referrals, and eventually, a diagnosis. By then, the body may have already crossed a threshold. The opportunity for prevention has passed.

“We’ve trained ourselves to respond to crisis instead of investing in clarity,” said David Medvedeff, CEO of Radence. “But it doesn’t have to be that way.”

Today, the landscape of healthcare is shifting. Groundbreaking advancements in science and technology are making it possible to detect risks and uncover disease long before symptoms arise. This is more than just progress. It’s an invitation to take ownership of personal health in a way that is proactive, precise and deeply empowering.

Protect What Matters Most

Conventional healthcare was built to intervene after illness begins. Even individuals with access to premium services often find themselves navigating a fragmented system of multiple specialists, disjointed testing, and a lack of holistic insight to optimize wellness.

“What people want isn’t more information,” Medvedeff said. “They want precise data-driven actions. They want to trust that they’re seeing the full picture and that nothing important is being missed.”

Discerning individuals expect more. There is a desire to understand and protect what matters most before it’s at risk. That’s where comprehensive early detection and prevention enters the conversation.

Empowered by Early Detection

The real power of early detection lies in what it makes visible, revealing the silent chronic illnesses that often progress unnoticed including cancer, cardiovascular, metabolic, and neurological diseases. Radence expertly develops best-in-class proprietary protocols for advanced testing, such as organ-specific MRIs, Whole Genome Sequencing, multi-cancer screening, and advanced cardiac imaging to provide an unprecedented and personalized view into the body’s future risks.

“It’s not a contest to see how many biomarkers we can tally, that’s a fool’s game,” Medvedeff said. “It’s about selecting the right tests, the ones grounded in science, personalized to each member’s ROI, that can reveal meaningful insight we can do something about.”

This level of precision allows for focused, evidence-based decisions. It eliminates guesswork and brings clarity.

Access to Actionable Health Insight

When approached with purpose, early detection data is not about overwhelming people with numbers and potentially creating unnecessary anxiety. It’s about providing actionable insights. A well-designed early detection and prevention strategy offers more than information. It delivers confidence. “Let’s face it, if you have cancer or cardiovascular disease you will know about it one day. The question is do you want to know about it early, when it is highly treatable, or would you rather wait and see if conventional medicine can do something heroic for you. Either way, you will know about it,” Medvedeff said.

Early detection provides the answer. And it does so in a way that allows for data-driven decision making early enough to have an impact on the future. This is an advancement in the past few years that is only just coming to light, one that Radence members can have now and will eventually change the face of medical care for everyone.

A Trusted, Multimodal Approach

Trust is the cornerstone of any healthcare relationship. It is built on integrity. Offering a higher standard of care means consistently aligning science, service, and empathy.

“True luxury in healthcare is knowing that your care is grounded in science, delivered with accuracy, and tailored to you as a whole person,” Medvedeff said.

Radence’s multimodal approach integrates precision medicine with thoughtful, personalized guidance in partnership with our members’ trusted physicians and concierge doctors. It ensures that no result is left unexamined, and that each next step is considered with care and in context of one’s personal and family health history and concerns.

The Radence Standard of Care

When precision medicine and advanced early detection meet highly personalized, compassionate care, the result is a healthcare experience rooted in science, wisdom and excellence. This is the Radence Standard of Care: anticipatory, personalized, and scientifically sound.

“The future of healthcare is here,” Medvedeff said. “And it’s time we hold our health to the same higher standard we hold for every other aspect of our lives. Now is the time to embrace clarity, pursue insight, and choose prevention. Because health, at its best, is not only about avoiding illness. It’s about creating the conditions to add more life to every year. ”

 

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Narrowed artery partially blocked

Understanding Atherosclerosis, Cardiovascular Disease, and Stroke Risk

Atherosclerosis is a condition that affects millions of people worldwide, often without warning. It plays a central role in the development of both heart disease and stroke, two of the leading causes of death and disability. Understanding what atherosclerosis is, who is most at risk, and the importance of early screening can significantly affect long-term health outcomes.

What is Atherosclerosis?

Atherosclerosis refers to the buildup of plaque, composed of cholesterol, fatty substances, calcium, and other materials, inside the walls of arteries. Over time, this buildup can narrow arteries and restrict blood flow to vital organs such as the heart and brain. If a plaque ruptures, it can trigger the formation of a blood clot, leading to a heart attack or stroke.

Often called a silent disease, atherosclerosis can develop slowly over many years without causing symptoms until a major cardiovascular event occurs.

Why is Atherosclerosis Important?

Atherosclerosis is the underlying cause of most cardiovascular (heart) and cerebrovascular (brain) events. Consider the following:

Heart disease remains the leading cause of death globally. This is the main reason why Radence is focused on it as a key area from the beginning. Stroke is the second leading cause of death worldwide and a major cause of long-term disability. The risk of confounding health issues after a stroke is multiplied. Many individuals with advanced atherosclerosis experience no symptoms until a heart attack or stroke happens. In fact, statistics from the Barnes-Jewish Hospital show that about 70% of people who have a stroke were asymptomatic before.

The ability to detect and manage atherosclerosis early can prevent these life-altering events and significantly improve both quality of life and longevity.

Who is Most at Risk?

Numerous dietary, lifestyle, and demographic factors can increase the likelihood of developing atherosclerosis, and here are some of the biggest influencers:

Diabetes High blood sugar can damage the inner layers of the arteries, leading to plaque buildup increasing risk for diabetes. Diabetes itself is a risk factor for numerous additional chronic diseases, including cardiovascular disease and stroke. Family History Genetics can raise your risk — especially if you have an inherited cholesterol disorder like familial hypercholesterolemia, which affects about 1 in 300 people. There are other important genetic predispositions Radence takes into account when assessing risk with a complete genetic profile. High Blood Pressure High blood pressure, or hypertension, quietly harms your body over time by damaging your arteries and helping plaque buildup, which can lead to heart attacks or strokes. It’s known as a silent risk factor because it usually has no symptoms, but it’s incredibly common. In fact, about 1 in 2 adults in the US has high blood pressure, often without realizing it. It’s the No. 1 controllable cause of death related to heart disease, which makes early detection and management especially important. Inflammation and Inflammatory Diseases Conditions like rheumatoid arthritis or psoriasis cause chronic inflammation that can injure blood vessels and promote plaque formation. People can still have uncontrolled inflammation from environmental, lifestyle, and biological factors too, from air pollution, chemical exposures, poor gut health, lack of quality sleep, processed sugars or low fiber intake — all contributing to persistent low-grade inflammation and increasing risk for heart disease. Lack of Physical Activity Sedentary lifestyles, like prolonged sitting, lack of purposeful movement, and loss of skeletal muscle mass are associated with unfavorable cholesterol profiles that contribute to atherosclerosis and cardiometabolic risk. Older Age Plaque buildup often begins in childhood and worsens with age. Risk increases in men after age 45 and in women around age 55 as estrogen levels decrease through menopause. Risk is also higher in younger women with endometriosis, polycystic ovary syndrome, gestational diabetes, or preeclampsia during pregnancy. Overweight or Obesity Obesity or carrying excessive weight in the abdomen is a metabolic and vascular disease accelerator and increases risk for heart disease and related conditions like type 2 diabetes and certain cancers. Statistics show nearly 3 in 4 adults (age 20+) in the US are overweight or obese. Obesity is starting at an earlier age too. Nearly 1 in 5 children and teens (ages 2–19) are considered obese, emphasizing the importance of early screening to avoid long-term consequences. Race and Ethnicity Race and ethnicity play a significant role in the risk for atherosclerotic cardiovascular disease (ASCVD), with certain populations experiencing a disproportionately higher prevalence of disease. Black or African American individuals in the US are at a 30% higher risk for hypertension, stroke, heart failure, and premature ASCVD compared to white individuals, often due to a combination of genetic susceptibility, socioeconomic factors, and reduced access to preventive care. Hispanic and South Asian populations also face elevated ASCVD risk, with South Asians demonstrating higher rates of insulin resistance, central obesity, and cholesterol abnormalities, often at lower BMI levels, contributing to earlier onset and more aggressive cardiovascular disease. Additionally, Native American and Alaska Native populations experience some of the highest rates of obesity, diabetes, and metabolic syndrome, all of which are potent drivers of ASCVD. These disparities underscore the need for personalized, culturally aware, and early prevention strategies tailored to high-risk racial and ethnic groups. Smoking and Secondhand Smoke About 1 in 3 coronary heart disease deaths are linked to smoking or secondhand smoke. Even exposure to secondhand smoke can contribute to atherosclerosis and stroke. Risk also increases with pack years, even if you haven’t smoked recently. Unhealthy Diet While certain foods may be helpful to minimize risk, other foods can play a role in increasing risk. High intake of saturated fats (from meat and full-fat dairy), when not part of a well-formulated diet, healthy weight, and exercise plan, raises cholesterol. Similarly, excessive alcohol or binge drinking can also elevate total cholesterol and impact inflammation markers.

Radence screens for atherosclerosis and cardiometabolic risk earlier and even in individuals considered low risk by these conventional standards because a significant proportion of disease develops silently and is often missed by traditional screening tools.

Symptoms: Often Absent Until Advanced Disease

Undetectable atherosclerosis, early signs of insulin resistance, and visceral adiposity can be present years before symptoms or abnormal labs emerge. Evidence shows that early vascular and metabolic changes can lead to irreversible damage if left unaddressed, and that intervening (with non-invasive modifications to diet and lifestyle) in these early stages and younger years dramatically reduces future cardiovascular events, stroke, and diabetes risk.

One of the challenges with atherosclerosis is that it frequently progresses unnoticed by simple point in time, single tests. When symptoms do arise, they can include:

Chest pain or discomfort (angina) including back, shoulder and neck and arm pain Shortness of breath Numbness, weakness, or paralysis (often on one side of the body, indicating stroke) Sudden difficulty speaking, seeing, or walking Feeling lightheaded or dizzy Heart palpitations Fatigue

By the time symptoms like chest pain or stroke occur, the disease is often advanced, more difficult to manage, and requires more invasive testing and interventions. Unfortunately, for many, the first sign of atherosclerosis could be a major cardiovascular or cerebrovascular event which can have profound consequences. Even individuals who feel healthy and have no symptoms may still be at elevated risk due to the environmental, demographic, and lifestyle factors.

The Role of Early Detection Screening

Early screening plays a critical role in identifying future risk for atherosclerosis and cardiometabolic dysfunction — often years before symptoms develop or a formal diagnosis is made. Atherosclerosis begins with inflammation, endothelial damage, lipid abnormalities, and insulin resistance progressively impairing vascular health.

Early detection enables early intervention, which can prevent irreversible vascular damage and reduce the lifetime risk of cardiovascular events, diabetes, and related diseases. Radence takes a proactive, precision-based approach that combines advanced imaging, metabolic biomarkers, and longitudinal monitoring to identify risk before it becomes clinically apparent. This enables timely lifestyle and therapeutic interventions that are more effective, less invasive, and ultimately help members maintain health span — not just lifespan.

Key findings support early screening using the comprehensive testing protocol that Radence recommends:

In research studies, 61% of individuals with “low risk” have atherosclerotic plaque identified via carotid ultrasound1​. Ultrasound is a valuable, non-invasive test Radence uses as part of a multimodal approach to stratify a member’s health risk. Testing has been associated with significantly improved adherence to preventive treatments, including lifestyle changes and medication initiation​.2 The ultimate goal is to prevent disease. Radence takes steps to help members change the trajectory of their health risk with proactive measures. Detecting plaque early can allow for more aggressive management of cholesterol, blood pressure, and other risk factors to prevent heart attacks and strokes before requiring invasive treatment. A member’s care plan is tailored to them. How to Reduce Your Risk

Atherosclerosis is a serious and progressive condition that is often undetectable without medical imaging. By recognizing personal risk factors, undergoing appropriate testing, and initiating preventive strategies early, Radence members can greatly reduce their risk of heart attack, stroke, and other complications.

At Radence, we are committed to proactive health management. Carotid ultrasound, blood work, genetics, body composition, and other gold-standard testing modalities are valuable components of a comprehensive approach to preserving cardiovascular and neurological health, providing invaluable data about your future.

No matter if you are asymptomatic, have risk factors, or wish to better understand your vascular health, Radence will help put you on a personalized data-driven path to proactive health.

Investing in prevention today can help safeguard your health for years to come.

 

Chen CH, Hung CL, Po HL, et al. Early detection of subclinical atherosclerosis in asymptomatic patients assessed by carotid duplex and coronary computed tomography. Int J Gerontol. 2013;7(1):27-34. Johnson HM, Turke TL, Grossklaus M, et al. Effects of an office-based carotid ultrasound screening intervention. J Am Soc Echocardiogr. 2011;24(7):738-747.

 

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David Medvedeff, Radence CEO

Building Trust in Preventive Medicine

I recently sat down with David Medvedeff, our Radence CEO, at Palm Beach’s famed The Breakers Resort to talk about Radence, as we anticipate the opening of the West Palm Beach Innovation Hub and member office this summer. As a serial successful health care startup leader, David knows better than most what is missing for patients, and their doctors, looking for care to extend health span and reduce chronic illness using science-backed testing.

He explained that in many areas of healthcare, progress is measured by access to more — more tests, more data, more interventions. As a trained pharmacist, he has seen first-hand that more doesn’t always mean better, and meaningful impact is the result of personalization. Without thoughtful curation, an abundance of medical information can overwhelm rather than inform. The vision for Radence, first incubated within RA Capital Management, a leader in biopharmaceutical innovation, is to develop a different approach to early detection and preventive care: one grounded in scientific discipline, careful prioritization, and collaborative thinking.

Partnering with Primary Care Doctors

The goal isn’t to flood the system with diagnostics. It’s to choose the right test, for the right person, at the right time — and to do so in partnership with concierge and primary care doctors and medical team who already play a central role in  caring for their patients. Proven advancements in managing the risks of chronic illness through insights at the cellular level have changed the game when it comes to optimizing health span, however, their wider use is only just beginning.

“We’re not trying to replace anyone’s doctor,” Most physicians we work with have decades-long relationships with their patients.” He emphasized, “Our job is to complement their practice, to give Radence members and their doctors access to research and precision data they wouldn’t otherwise have. Radence is concierge science, tirelessly supporting our stakeholders as their partner in precision medicine, no different than how a cardiologist or neurologist would be engaged.”

Personalized Precision Care

Recognizing the busy lives and needs of their clients inspired a shift in the way the company is set up to accommodate member care wherever they are in the world. Radence avoids the typical health-tech formula. There are no company-owned scanning centers or fleets of proprietary machines. Instead, it’s a distributed network — coordinated testing in the locations where members reside, relying on best-in-class verified expert partners rather than an in-house infrastructure. The intent is to remain adaptable and to avoid a one-size-fits-all battery of tests and scans to justify fixed costs.

“Once a company buys an MRI or a PET scanner, the business becomes about utilization. In that model, whether an individual needs a given test becomes secondary,” David said. “We’ve intentionally stayed away from that. Radence takes a more deliberate approach, focused on personalized precision care.”

Driven by Science

In my time standing up this business with our clinical team, I have learned that our personalized precision approach happens across several layers with the best-informed proprietary protocols in the industry: genomic sequencing, imaging, biomarkers, cognitive assessments, and comprehensive consultations. Each test result is evaluated in a specific sequence not only on what it can reveal, but on what it might obscure or complicate. This multi-modal approach is a sharp contrast to much of what is being promoted today to extend health span.

Behind the scenes, the work is supported by medical experts, scientists, and research partners who monitor emerging technologies, clinical trials, and scientific advancements. This ensures that the care and service Radence members receive is the most leading-edge option science has to offer.

Greater Depth and Accuracy

Members begin with a comprehensive baseline evaluation, followed by tailored engagement throughout the year. This may include additional testing, risk modeling, or targeted follow-up depending on each member’s personal health profile. Over time, the goal is to create a deeper and more accurate understanding of how your health changes and what steps might matter most going forward.

Relevant, Actionable Health Insight

Radence believes that in providing the best forecast of members’ future health, the emphasis remains on context over volume.

“There’s a temptation to think that more information is always better,” David said. “But without structure, it becomes noise and can seed anxiety for both the patient and doctor. Our role is to interpret and prioritize, to give members and their doctors relevant, actionable health insight focused on enhancing peace of mind. That’s why our protocols are tailored not only to biological risk but also to psychological readiness.”

That philosophy extends to the thoughtful way information is communicated. When results are shared with physicians, the aim is to avoid overwhelming with raw outputs, and offer clear, clinically relevant reports they can use in decision-making. This serves to support the physician’s role rather than compete with it.

What Matters Most

Radence is focused on what the company calls Health Assurance. For many, time and access can be limiting factors. By coordinating services locally, where members reside, delivering health insights early, and partnering with medical teams, Radence builds trust and offers a seamless, elevated, member experience. What emerges is a higher standard of care empowering members to make data-driven decisions early enough to impact future outcomes and change what health care will be for generations to come.

 

 

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